Clostridioides difficile Infection
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Benign Disease- A 55-year-old otherwise healthy woman presents with tachycardia, abdominal pain, and diarrhea after taking antibiotics. Computed tomography (CT) shows pancolitis. Infectious workup is positive for Clostridioides difficile (C. diff). She has never had C. diff colitis. What is the initial therapy recommended for her?
- A 26-year-old patient who was admitted to the hospital with ulcerative colitis (UC) continues to have frequent bloody bowel movements and tachycardia despite intravenous (IV) steroids and cyclosporine. Which is the most appropriate next step?
- A 38-year-old man returns from a 1-week trip to Africa, where he had sampled the local cuisine and drank the water. On his return, he develops fever and bloody diarrhea. Other symptoms included abdominal pain, nausea and vomiting. His symptoms did resolve independently over the course of the next week. Within a few days of gastrointestinal symptom resolution, the patient developed neurologic symptoms consistent with Guillan-Barre syndrome. Which of the following gastrointestinal illnesses is he most likely to have contracted?
- A 78-year-old woman is diagnosed with Clostridioides difficile colitis, intially presenting with frequent diarrhea and mild abdominal pain. Despite appropriate antibiotic therapy with oral vancomycin and fluid resuscitation, she develops progressive hypotension, tachycardia, worsening abdominal pain, and altered mental status. The best next step in management is
- A 42-year-old previously healthy woman presents to the emergency department with 2 weeks of right lower quadrant abdominal pain and diarrhea. Computed tomography (CT) of the abdomen and pelvis shows terminal ileitis and associated enlarged mesenteric lymph nodes. Serologic testing for which of the following should be performed?
Perioperative







