Management of Anal Dysplasia
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Anorectal Disease
Malignancy- A 62-year-old woman presents to the office with a 1-month history of rectal pain, bleeding, and perianal mass. On digital rectal examination and anoscopy, a 3-cm firm mass is noted at the left lateral anal canal. Inguinal examination is unremarkable. Biopsy of the mass shows moderately differentiated squamous cell carcinoma. Staging computed tomography (CT) of the chest and abdomen and magnetic resonance imaging (MRI) of the pelvis demonstrate a T2N1M0 tumor. What is the best next step in her management?
- A healthy 51-year-old man has a poorly differentiated right colon adencarcinoma with mucinous features and mismatch repair (MMR) deficient protein expression. After germline testing was performed, a diagnosis of Lynch syndrome made. The patient reports no issues with incontinence to gas or stool. What is the recommended surgery in this patient?
- A 40-year-old woman is referred to you because of a 6-month history of painful hemorrhoids that have not been responsive to topical therapy and stool softeners. A 3-cm, ulcerated, hard mass extending into the anal canal is found on perianal examination and biopsied. Pathology comes back as anal squamous cell cancer. What is the most appropriate next step?
Benign Disease






