ASCRS U | Adjuvant Therapy for Rectal Adenocarcinoma

Adjuvant Therapy for Rectal Adenocarcinoma

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Adjuvant Therapy for Rectal Adenocarcinoma
- References
Rectal Cancer: Neoadjuvant Therapy
- References
Management of Rectal Cancer 2023 Supplement (2023)
- References
- STATEMENT OF THE PROBLEM
- CERTAINTY OF EVIDENCE
Malignancy
- A healthy 65-year-old male patient is diagnosed with a moderately differentiated rectal adenocarcinoma, microsatellite stable. Staging was negative for metastatic disease. Pelvic magnetic resonance imaging (MRI) shows possible involvement of the prostate with mesorectal lymph nodes suspicious for metastasis. What is the current recommended course of treatment for this patient, given these findings?
Surveillance After Rectal Cancer Treatment
- References
Benign Disease
- A 55-year-old man with a history of ulcerative colitis (UC) diagnosed in his early 20s presents with a new diagnosis of distal rectal moderately differentiated adenocarcinoma. Mismatch repair (MMR) protein expression is intact; routine surveillance endoscopy showed a mass starting ~2 cm from the anal verge with all other biopsies negative for dysplasia. Laboratory results reveal unremarkable levels of carcinoembryonic antigen (CEA), comprehensive metabolic panel (CMP), and complete blood count (CBC). Systemic staging is negative for metastatic disease. Local staging with magnetic resonance imaging (MRI) reveals a T3N1 lesion. Based on a multidisciplinary tumor board discussion, the patient is planned for total neoadjuvant chemotherapy with upfront chemoradiation followed by consolidation chemotherapy. After this therapy is completed, what is the optimal surgical course for this patient?
Rationale for Multimodality Therapy
- References
Colorectal Cancer: Postoperative Adjuvant Therapy and Surveillance
- References
Rectal Cancer: Local Excision
- References
Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer (2021)
- A. Risk Assessment and Stratification
- B. Surveillance
- References
Indications for Neoadjuvant Therapy
- References
Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma
- Neuroendocrine Tumors (NETs)
- Lymphoma
Management of Rectal Cancer (2020)
- References
Local Excision
- References
Management of Local Recurrences
- References
Colorectal Cancer: Preoperative Evaluation and Staging
- References
Anal Cancer
- References
- Anal Canal Squamous Cell Carcinoma
Management of Colon Cancer (2022)
- References
Colorectal Cancer: Management of Distant Metastases
- References
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
- References
Presacral Tumors
- References
Management of Appendiceal Neoplasms (2025)
- References
Anal Squamous Cell Cancers (Revised 2018)
- References
1 - 30 of 30 records

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