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An 18-year-old man with a 2-year history of Crohn’s disease treated with budesonide and 6-mercaptopurine is admitted for increased right lower quadrant pain, diarrhea, and weight loss. Computed tomography shows an ileal phlegmon. Colonoscopy shows significant deep ileal ulcers and erythema in the transverse colon. The best next step in management is:

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