Sporadic and Inherited Colorectal Cancer: How Epidemiology and Molecular Biology Guide Screening and Treatment
Key Concepts
- Colorectal cancer is caused by the accumulation of a variety of genetic alterations in colonic mucosa.
- Colorectal cancer can be hereditary or sporadic (not inherited). Both forms share many of the same genetic alterations.
- Multiple hereditary forms of colorectal cancer have an expected phenotype due to the genetic alteration that increases the likelihood of the cancer.
- Screening algorithms for colorectal cancer differ between hereditary and sporadic cancer based on the time expected for an adenoma to become a carcinoma in that patient.
- Hereditary forms of colorectal cancer are more commonly seen in patients with young onset colorectal cancer.
- Treatment algorithms for hereditary colorectal cancer are directed towards removal of the cancer and decreasing future risk of additional cancers.
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Last updated: January 26, 2022
Citation
Glasgow, Sean C, and Karin M Hardiman. "Sporadic and Inherited Colorectal Cancer: How Epidemiology and Molecular Biology Guide Screening and Treatment." ASCRS Textbook of Colon and Rectal Surgery, 2022. ASCRS U, www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285015/all/Sporadic_and_Inherited_Colorectal_Cancer:_How_Epidemiology_and_Molecular_Biology_Guide_Screening_and_Treatment.
Glasgow SC, Hardiman KM. Sporadic and Inherited Colorectal Cancer: How Epidemiology and Molecular Biology Guide Screening and Treatment. ASCRS Textbook of Colon and Rectal Surgery. 2022. https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285015/all/Sporadic_and_Inherited_Colorectal_Cancer:_How_Epidemiology_and_Molecular_Biology_Guide_Screening_and_Treatment. Accessed June 8, 2023.
Glasgow, S. C., & Hardiman, K. M. (2022). Sporadic and Inherited Colorectal Cancer: How Epidemiology and Molecular Biology Guide Screening and Treatment. In ASCRS Textbook of Colon and Rectal Surgery https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285015/all/Sporadic_and_Inherited_Colorectal_Cancer:_How_Epidemiology_and_Molecular_Biology_Guide_Screening_and_Treatment
Glasgow SC, Hardiman KM. Sporadic and Inherited Colorectal Cancer: How Epidemiology and Molecular Biology Guide Screening and Treatment [Internet]. In: ASCRS Textbook of Colon and Rectal Surgery. ; 2022. [cited 2023 June 08]. Available from: https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285015/all/Sporadic_and_Inherited_Colorectal_Cancer:_How_Epidemiology_and_Molecular_Biology_Guide_Screening_and_Treatment.
* Article titles in AMA citation format should be in sentence-case
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