Key Concepts

• Treatment of advanced colorectal cancer has evolved significantly over time, reflecting a shift toward more aggressive therapy recognizing the potential for long-term survival.
• The liver is the most common site of metastatic disease followed by the lung. The brain, bone, ovary, peritoneum, and adrenals make up the remaining less common sites of metastatic disease.
• Treatment options depend on the functional status and primary goals of the patient, site and volume of metastatic disease, as well as the degree of symptoms from the primary tumor.
• Treatment of the patient with metastatic colorectal cancer requires a comprehensive multidisciplinary approach to develop an individualized treatment scheme integrating quality of life and patient needs.