Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma

Karim Alavi, Marylise Boutros
Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma is a topic covered in the ASCRS Textbook of Colon and Rectal Surgery.

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Key Concepts

  • The majority of gastrointestinal stromal tumors (GISTs) stain positive for CD117 and have an alteration in c-kit proto-oncogene.
  • Surgical excision with a 1–2 cm margin is the preferred treatment for GISTs located in the rectum.
  • Treatment of midgut neuroendocrine tumors (NETs) is segmental resection with lymphadenectomy.
  • Somatostatin analogs control the symptoms of carcinoid syndrome and help limit the progression of disease.
  • Rectal NETs less than 1 cm in diameter may be treated by endoscopic or local excision, while tumors greater than 2 cm should be considered for radical resection.
  • Patients with symptomatic colonic lymphomas are best treated with surgical resection prior to chemotherapy.

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Key Concepts

  • The majority of gastrointestinal stromal tumors (GISTs) stain positive for CD117 and have an alteration in c-kit proto-oncogene.
  • Surgical excision with a 1–2 cm margin is the preferred treatment for GISTs located in the rectum.
  • Treatment of midgut neuroendocrine tumors (NETs) is segmental resection with lymphadenectomy.
  • Somatostatin analogs control the symptoms of carcinoid syndrome and help limit the progression of disease.
  • Rectal NETs less than 1 cm in diameter may be treated by endoscopic or local excision, while tumors greater than 2 cm should be considered for radical resection.
  • Patients with symptomatic colonic lymphomas are best treated with surgical resection prior to chemotherapy.

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Last updated: January 26, 2022