Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma
Key Concepts
- The majority of gastrointestinal stromal tumors (GISTs) stain positive for CD117 and have an alteration in c-kit proto-oncogene.
- Surgical excision with a 1–2 cm margin is the preferred treatment for GISTs located in the rectum.
- Treatment of midgut neuroendocrine tumors (NETs) is segmental resection with lymphadenectomy.
- Somatostatin analogs control the symptoms of carcinoid syndrome and help limit the progression of disease.
- Rectal NETs less than 1 cm in diameter may be treated by endoscopic or local excision, while tumors greater than 2 cm should be considered for radical resection.
- Patients with symptomatic colonic lymphomas are best treated with surgical resection prior to chemotherapy.
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Last updated: January 26, 2022
Citation
Alavi, Karim, and Marylise Boutros. "Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma." ASCRS Textbook of Colon and Rectal Surgery, 2022. ASCRS U, www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285028/all/Gastrointestinal_Stromal_Tumors__Neuroendocrine_Tumors__and_Lymphoma.
Alavi K, Boutros M. Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma. ASCRS Textbook of Colon and Rectal Surgery. 2022. https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285028/all/Gastrointestinal_Stromal_Tumors__Neuroendocrine_Tumors__and_Lymphoma. Accessed May 28, 2023.
Alavi, K., & Boutros, M. (2022). Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma. In ASCRS Textbook of Colon and Rectal Surgery https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285028/all/Gastrointestinal_Stromal_Tumors__Neuroendocrine_Tumors__and_Lymphoma
Alavi K, Boutros M. Gastrointestinal Stromal Tumors, Neuroendocrine Tumors, and Lymphoma [Internet]. In: ASCRS Textbook of Colon and Rectal Surgery. ; 2022. [cited 2023 May 28]. Available from: https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285028/all/Gastrointestinal_Stromal_Tumors__Neuroendocrine_Tumors__and_Lymphoma.
* Article titles in AMA citation format should be in sentence-case
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AU - Boutros,Marylise,
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BT - ASCRS Textbook of Colon and Rectal Surgery
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