Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Key Concepts
- Peritoneal dissemination is a frequent occurrence in the natural history of colorectal cancer, which may be synchronous or metachronous.
- The clinical benefit of systemic chemotherapy in patients with colorectal peritoneal metastases is less than in patients with other metastatic sites.
- A substantial survival benefit, with some patients cured, can be achieved in selected patients undergoing CRS and HIPEC.
- Outcome of CRS and HIPEC for colorectal peritoneal metastases is best in patients with low disease burden and complete cytoreduction.
- Currently, a shift in focus is taking place from treatment of established colorectal peritoneal metastases to prevention and early detection, by identification of patients at high risk for developing colorectal peritoneal metastases.
- Combining CRS and HIPEC with limited resection of liver metastases is feasible and achieves good oncological outcomes in a highly selected group of patients.
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Last updated: January 26, 2022
Citation
Valente, Michael A, and Brendan J Moran. "Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy." ASCRS Textbook of Colon and Rectal Surgery, 2022. ASCRS U, www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285029/all/Cytoreductive_Surgery_and_Hyperthermic_Intraperitoneal_Chemotherapy.
Valente MA, Moran BJ. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. ASCRS Textbook of Colon and Rectal Surgery. 2022. https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285029/all/Cytoreductive_Surgery_and_Hyperthermic_Intraperitoneal_Chemotherapy. Accessed December 9, 2023.
Valente, M. A., & Moran, B. J. (2022). Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. In ASCRS Textbook of Colon and Rectal Surgery https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285029/all/Cytoreductive_Surgery_and_Hyperthermic_Intraperitoneal_Chemotherapy
Valente MA, Moran BJ. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy [Internet]. In: ASCRS Textbook of Colon and Rectal Surgery. ; 2022. [cited 2023 December 09]. Available from: https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285029/all/Cytoreductive_Surgery_and_Hyperthermic_Intraperitoneal_Chemotherapy.
* Article titles in AMA citation format should be in sentence-case
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T1 - Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
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AU - Moran,Brendan,
Y1 - 2022/01/26/
BT - ASCRS Textbook of Colon and Rectal Surgery
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