Inflammatory Bowel Disease: Pathobiology
Key Concepts
- The pathophysiology of IBD is incompletely understood but thought to be multifactorial and a complex interaction between genetic, environmental, microbial, and immune factors.
- While hundreds of susceptibility genetic loci have been identified to increase the risk of disease, all identified loci individually contribute only a small percentage of the expected heritability in IBD.
- The significantly increasing incidence of IBD in developing urban countries worldwide lends strong evidence that environmental factors may play the dominate role in its pathogenesis.
- The composition of the gut microbiota is significantly different in patients with IBD and has increased colonization of Fusobacterium and members of the Proteobacteria phylum and decreased colonization of Firmicutes and Bacteroidetes. Yet, no single organism has been identified to be solely responsible for the development of IBD.
There's more to see -- the rest of this topic is available only to subscribers.
Last updated: January 26, 2022
Citation
Shogan, Benjamin D, and Pokala R Kiran. "Inflammatory Bowel Disease: Pathobiology." ASCRS Textbook of Colon and Rectal Surgery, 2022. ASCRS U, www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285038/all/Inflammatory_Bowel_Disease:_Pathobiology.
Shogan BD, Kiran PR. Inflammatory Bowel Disease: Pathobiology. ASCRS Textbook of Colon and Rectal Surgery. 2022. https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285038/all/Inflammatory_Bowel_Disease:_Pathobiology. Accessed December 9, 2023.
Shogan, B. D., & Kiran, P. R. (2022). Inflammatory Bowel Disease: Pathobiology. In ASCRS Textbook of Colon and Rectal Surgery https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285038/all/Inflammatory_Bowel_Disease:_Pathobiology
Shogan BD, Kiran PR. Inflammatory Bowel Disease: Pathobiology [Internet]. In: ASCRS Textbook of Colon and Rectal Surgery. ; 2022. [cited 2023 December 09]. Available from: https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285038/all/Inflammatory_Bowel_Disease:_Pathobiology.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Inflammatory Bowel Disease: Pathobiology
ID - 2285038
A1 - Shogan,Benjamin,
AU - Kiran,Pokala,
Y1 - 2022/01/26/
BT - ASCRS Textbook of Colon and Rectal Surgery
UR - https://www.ascrsu.com/ascrs/view/ASCRS-Textbook-of-Colon-and-Rectal-Surgery/2285038/all/Inflammatory_Bowel_Disease:_Pathobiology
DB - ASCRS U
DP - Unbound Medicine
ER -