Medical Management of Ulcerative Colitis

Amy L. Lightner, Scott A. Strong

Key Concepts

  • The goal of medical therapy for ulcerative colitis is steroid-free clinical remission with mucosal healing.
  • 5-ASA medications are the first-line treatment for low-risk patients with mild-to-moderate UC.
  • IV corticosteroids are first-line treatment for severe UC flare-ups requiring hospitalization.
  • Cyclosporin and infliximab are appropriate second-line agents for patients with steroid refractory severe acute colitis.

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Last updated: January 26, 2022