Management of Appendiceal Neoplasms

Glasgow Sean C. M.D.; Gaertner, Wolfgang M.D.; Stewart, David M.D.; Davids, Jennifer M.D.; Alavi, Karim M.D.; Paquette, Ian M. M.D.; Steele, Scott R. M.D., M.B.A.; Feingold, Daniel L. M.D.

Diseases of the Colon & Rectum. 62:p 1425-1438, December 2019.

doi: 10.1097/DCR.0000000000001530

CLINICAL PRACTICE GUIDELINES PDF | VISUAL ABSTRACT | PODCAST

STATEMENT OF THE PROBLEM

Historically, the estimated incidence of appendiceal tumors was 0.12 cases per 1,000,000 people per year; however, based on recent large database studies, the incidence may be as high as 0.97 per 100,000 population.[1],[2],[3] It is unclear whether this increase reflects an actual change in the disease occurrence or simply greater recognition and reporting. Although tumors of the appendix are rare, surgeons should be familiar with the implications of appendiceal pathology, because almost 300,000 appendectomies are performed annually in the United States, and neoplasia is found in ≈1% to 2% of these specimens.[4],[5],[6]

CLASSIFICATION BY HISTOPATHOLOGY

Given the rarity and multiple different terms used to describe appendiceal neoplasms, consistency regarding their classification not only allows for improved reporting but also for more precise management. In general terms, appendiceal neoplasms can be broadly described as epithelial, such as adenomas or adenocarcinomas, or nonepithelial (eg, neuroendocrine or lymphoma). The epithelial group is often further subdivided based on mucin production, because mucinous tumors have distinctly different biologic behavior and oncologic outcomes from nonmucinous neoplasms.[4] The World Health Organization classifies the majority of noninvasive epithelial lesions as low-grade appendiceal mucinous neoplasms (LAMNs).[7] Histologically, LAMNs are characterized by well-differentiated adenomas that can proliferate outside the appendix in a malignant fashion. Acellular or cellular extra-appendiceal mucin may be associated with LAMNs, although this is not a requirement. The LAMN terminology includes lesions that were described previously as mucoceles or mucinous cystadenomas, which are terms no longer in use. Some authors have suggested an intermediate grouping between traditional LAMNs and invasive carcinoma.[8] These LAMNs of uncertain malignant potential may exhibit gross perforation, mural fibrosis, mucin dissecting within the appendiceal wall, or acellular mucin in the periappendiceal soft tissues. High-grade appendiceal neoplasms (HAMNs) share some histologic features with LAMNs but exhibit more aggressive cytologic atypia. The distinct biological and clinical behaviors of HAMNs are poorly characterized.[9]

Appendiceal adenocarcinomas may be either mucinous or nonmucinous. Mucinous adenocarcinomas are characterized by invasive glands containing high-grade cytologic atypia and extracellular mucin in >50% of the lesion.[7] Appendiceal adenocarcinomas resemble their colorectal counterparts histologically, regularly expressing p53, CD44, and CDX2. They often demonstrate signet ring cells if poorly differentiated, are prone to lymphatic spread, and are staged according to the TNM classification. Goblet cell carcinoid tumors represent a variant of adenocarcinoma that demonstrates some features similar to traditional neuroendocrine tumors (NETs; eg, positive chromogranin A staining).[7] However, these mixed adenoneuroendocrine carcinomas are more aggressive than traditional NETs and should generally be treated in a similar manner to classic appendiceal adenocarcinomas.[10],[11]

Appendiceal neoplasms may perforate and spread throughout the peritoneal cavity.[12] When this spread includes abundant mucin production, the term pseudomyxoma peritonei (PMP) is used. Some authors make the distinction that PMP represents a clinical finding rather than a diagnosis and should be reserved for diffuse spread of mucin throughout the abdomen as opposed to mucin deposits that are confined adjacent to the appendix.[9] Because PMP often recurs after treatment and the 10-year overall survival (OS) rate after surgery for PMP is 63%, PMP should be considered a malignant condition.[13],[14] Variable degrees of cellularity within PMP can lead to vastly different patient prognoses.[11],[13],[15],[16] To reduce confusion and improve consistency in the literature, a consensus reporting classification was published recently for both PMP and appendiceal neoplasia.[14] The authors recommended categorizing PMP based on the degree of cellularity within the mucin as follows: acellular, low-grade histologic features, high-grade histologic features, and PMP with signet ring cells (Table 1). The low-grade group includes the commonly reported term of disseminated peritoneal adenomucinosis, whereas peritoneal mucinous carcinomatosis is designated as high grade. Because the grouping is based on histology, clinical features such as omental caking or ovarian involvement may represent either low- or high-grade PMP. This classification aligns with other schemes and helps determine treatment and prognosis.[17],[18]

Table 1.
Descriptive text is not available for this image
Histologic classification of PMP.

Nonepithelial appendiceal neoplasms include NETs. These lesions are histologically similar to those found elsewhere in the GI tract.[7] Appendiceal NETs are frequently asymptomatic and identified incidentally after routine appendectomy. Staging remains controversial and may be based on tumor size, depth of invasion, or degree of differentiation. Other rare nonepithelial appendiceal neoplasms include GI stromal tumors, lymphomas, and neural proliferations, which are not considered in this guideline.

METHODOLOGY

Selected members of the ASCRS Clinical Practice Guidelines committee drafted de novo position statements after performing a thorough search and review of the relevant literature. With input from the authors, a professional librarian conducted a systematic literature search encompassing January 1, 1997, to April 30, 2019, inclusive, across the Ovid Medline, Embase, and Scopus medical databases. Pertinent inclusion criteria were English language article and adult human patients, and both current and archaic terminology for appendiceal neoplasms were included as follows: (appendiceal, appendix, appendicular) AND (adenocarcinoma, carcinoma, mucinous, pseudomyxoma, signet*, cystadenoma, tumor*, tumour*, neoplasm, cancer). These groups were combined with various treatment modalities to include surgery and chemotherapy. Refer to Figure 1 for the full search algorithm. Directed searches of references in selected published articles yielded additional records. The initial search produced 2135 records after removal of duplicates. These were screened for relevance, yielding 901 abstracts for review as the basis for the recommendations. A directed search of references embedded in the candidate publications was performed. Emphasis was placed on prospective trials, meta-analyses, systematic reviews, and practice guidelines. Peer-reviewed observational studies and retrospective studies were included when higher-quality evidence was insufficient. The final source material used was evaluated for methodologic quality, the evidence base was examined, and a treatment guideline was formulated by the subcommittee. The final grade of recommendation and level of evidence for each statement were determined using the Grades of Recommendation, Assessment, Development, and Evaluation system (Table 2). When agreement was incomplete regarding the evidence base or treatment guideline, consensus from the committee chair, vice chair, and 2 assigned reviewers determined the outcome. Members of the American Society of Colon and Rectal Surgeons (ASCRS) Clinical Practice Guidelines Committee worked in joint production of these guidelines from inception to final publication. Recommendations formulated by the subcommittee were reviewed by the entire Clinical Practice Guidelines Committee. Final recommendations were approved by the ASCRS Executive Committee. In general, each ASCRS Clinical Practice Guideline is updated every 5 years.

Table 2.
Descriptive text is not available for this image
The GRADE System: grading recommendations.
Figure 1.
Descriptive text is not available for this image
Literature search flow sheet. CPG = Clinical Practice Guidelines.

GENERAL CONSIDERATIONS

1. Patients with appendiceal neoplasms should undergo a complete history and physical examination. Grade: Strong recommendation based on low-quality evidence, 1C.

Neoplasms of the appendix are not often suspected before surgery and may be discovered either intraoperatively or incidentally in the pathologic specimen. Vague symptoms of fatigue, weight gain, chronic abdominal pain, and early satiety may be signs of advanced disease. Tumors can also present as appendicitis, bowel obstruction, or a pelvic mass.[19],[20] A thorough history and physical examination are essential. History should include previous surgical history, particularly appendectomy, with review of the associated operative note and pathology report, because patients may not be aware of the presence of an incidental neoplasm or mucin. Pathology slides should typically be reviewed in cases of diagnostic uncertainty. Physical examination should include a pelvic and digital rectal examination to assess for pelvic masses and mobility of surrounding structures. Rare presentations of mucinous appendiceal neoplasms include findings of pseudomyxomatous material in ventral, incisional, and inguinal hernias.[21],[22]

Although decision-making for performing an interval appendectomy after initial nonoperative management of presumed appendicitis is complex, the surgeon must consider that the risk for occult appendiceal neoplasm appears greater in this subgroup compared with the general population.[23],[24],[25],[26],[27],[28] Modern retrospective and database studies suggest an incidence of malignancy between 2.3% and 12.0%; in particular, older age and indeterminate imaging appear to be significant risk factors for appendiceal cancer.[23],[24],[26],[27] Periappendiceal abscess may be an even stronger predictor of occult neoplasm; the Finnish Peri-Appendicitis Acuta multicenter randomized controlled trial found an overall neoplasm incidence of 20% in these patients.[27] At a minimum, patients should be informed of this risk.

2. Colonoscopy should be performed in patients with confirmed or suspected appendiceal neoplasms. Grade: Strong recommendation based on low-quality evidence, 1C.

Patients with appendiceal neoplasms are at increased risk of harboring synchronous colonic lesions compared with the general population, with population-based studies reporting 13% to 42% of patients with primary epithelial appendiceal lesions having concurrent colorectal neoplasia.[5],[6],[29],[30] In a population-based study from the Netherlands from 1995 to 2005 that included 1482 patients with an appendiceal epithelial neoplasm, 193 (13%) had an incidental colonic adenoma (n = 37) or adenocarcinoma (n = 156).[5] In this study, the primary pathology of the appendiceal neoplasms was reported as mucinous cystadenoma (32%), mucocele (31%), and nonmucinous adenoma (26%), and the majority of the colonic adenocarcinomas discovered were right sided. By comparison, single-institution studies suggest that < 4% of patients with colorectal cancer have synchronous appendiceal neoplasms.[31],[32] In a single-surgeon series of 169 consecutive patients who underwent prophylactic appendectomy during segmental resection for colorectal cancer (including 63 right colectomies), the rate of incidental appendiceal neoplasia was 4%.[32] Although appendiceal neoplasms are rarely diagnosed at the time of colonoscopy, they may present endoscopically with an inverted or mass-like protrusion or mucous or polypoid tissue at the appendiceal orifice.[30],[33]

3. Appendectomy should be performed if a grossly abnormal appendix is encountered during an unrelated abdominal operation. Grade: Strong recommendation based on low-quality evidence, 1C.

During an abdominal or pelvic operation, appendectomy is warranted for incidental findings of luminal dilation, serosal puckering or irregularity, or a mass. Care should be taken to avoid intraoperative perforation and spillage, and conversion to open surgery may be necessary in certain situations.[34],[35],[36] In a small series of 24 consecutive patients with appendiceal mucinous neoplasms, all were managed laparoscopically without intraoperative spillage. In this series, the majority required partial cecectomy (15/24; 62.5%) or ileocecectomy (8/24; 33.3%), whereas 1 patient underwent simple appendectomy.[37] The extent of resection is predominantly based on involvement of the base of the appendix. The priority is obtaining a pathologic diagnosis with a grossly negative margin. In most cases, appendectomy or partial cecectomy is sufficient when an abnormal appendix is encountered incidentally. When performing a laparoscopic approach, surgeons should consider using a specimen retrieval bag to help avoid spilling mucin.

An incidental finding of intraperitoneal mucin suggests the presence of a mucinous neoplasm of the GI or gynecologic tracts. In this setting, careful inspection of the appendix (and adnexa in a female patient) is warranted. Data from multiple retrospective, single-institution studies do not support routine appendectomy for a normal-appearing appendix in the setting of an ovarian mucinous neoplasm, because the incidence of synchronous appendiceal pathology in these cases is low.[38],[39],[40]

APPENDICEAL NETS

4. Preoperative assessment of patients with appendiceal NETs should typically include history and physical examination, colonoscopy, and CT or MRI of the chest, abdomen, and pelvis. Grade: Strong recommendation based on low-quality evidence, 1C.

Preoperative evaluation of patients with appendiceal NETs should involve a thorough history and physical examination, with a review of systems that specifically document the presence or absence of symptoms that could be associated with carcinoid syndrome, such as facial flushing, diarrhea, and dyspnea. NETs arising from the small intestine or from the colon are associated with higher rates (15%–30%) of synchronous NETs compared with appendiceal NETs, the latter having a low incidence of synchronicity often uncalculated in many series.[41] Irrespective of the risk of synchronous NETs, a preoperative colonoscopy is important because of the association of NETs with synchronous noncarcinoid neoplasms.[42] A series of 13,715 NETs from various body regions, including different segments of the alimentary tract, reported a synchronous cancer rate of 22.4% for the entire NET cohort.[43] Smaller series report similar rates of synchronous malignancies, with colorectal cancers representing between 25% and 50% of these synchronous lesions.[44],[45] Because appendiceal NETs can metastasize to the liver, as well as to the lungs, and because the management of metastatic NET differs from nonmetastatic appendiceal NET, patients should typically undergo clinical staging with an intravenous, contrast-enhanced CT or MRI of the chest, abdomen, and pelvis.

5. NET-specific imaging is not required for all patients with appendiceal NETs. Grade: Weak recommendation based on moderate-quality evidence, 2B.

Because most appendiceal NETs will express somatostatin receptors, somatostatin receptor scintigraphy (SRS) can be used to identify foci of NETs.[46] Furthermore, because SRS can confirm that enhancing lesions express somatostatin receptors, this study is useful in supporting the selection of somatostatin receptor antagonists as therapy in settings of locally advanced or metastatic disease.[47] With the fine resolution of modern CT and MRI, complementary use of SRS provides the highest yield in cases of indeterminate findings for potentially metastatic disease based on CT and MRI and in patients with symptoms consistent with carcinoid syndrome (eg, flushing, diarrhea, and bronchospasm). Although ≈80% or more of NETs will express somatostatin receptors, suggesting that SRS is likely to reveal the presence of an NET,[48] there are insufficient data to support the routine use of SRS for routine surveillance.

Positron emission tomography (PET)-CT scans are an additional imaging modality for evaluating metastatic disease from appendiceal NETs. In comparison with traditional 2-[18F] fluoro-2-deoxy-d-glucose PET-CT, SRS is more sensitive for detection of well-differentiated NETs (eg, those expressing somatostatin receptors), whereas 2-[18F] fluoro-2-deoxy-d-glucose PET detects more poorly differentiated tumors.[49] More recently, (68Ga)dotatate PET-CT has been shown to be equivalent or superior to SRS for detecting gastroenteric NETs.[50] In 1 study, (68Ga)dotatate PET-CT detected occult lesions in 65.2% of NET patients with negative biochemical testing, 40% of which were not present on SRS.[51] The use of routine (68Ga)dotatate PET-CT imaging should be balanced with the high cost of these studies.

6. Biochemical testing should be performed in patients with localized or metastatic appendiceal NETs to establish baseline measures for future surveillance and disease monitoring. Grade: Weak recommendation based on moderate-quality evidence, 2B.

Appendiceal NETs are not commonly biochemically active unless there is a significant burden of hepatic metastatic disease. The most common metabolites produced by appendiceal NETs include chromogranin A and 5-hydroxyindoleacetic acid, the former evaluated with serum and the latter with a 24-hour urine collection. Elevated levels of either of these metabolites have been associated with poor prognosis.[52],[53] Importantly, these markers are not reliable for the purposes of diagnosing the presence of an NET or for guiding therapeutic decisions.[54],[55]

7. Extent of surgical resection of appendiceal NETs is determined by tumor size and histologic features. Grade: Strong recommendation based on low-quality evidence, 1C.

For nonmetastatic NETs confined to the appendix, treatment is generally based on the size of the primary tumor. Lesions < 1 cm in diameter and without unfavorable features are adequately treated with appendectomy taking care to remove the entire mesoappendix. Long-term disease-free survival in these patients is 100%.[56],[57],[58] Tumors >2 cm are best treated with formal right hemicolectomy, because the reported risk of nodal metastases may be as high as 40%.[56],[59],[60],[61] Appendiceal NETs between 1 and 2 cm in size have an intermediate risk of nodal metastases in most series.[56],[57],[62] However, the largest clinical series found no nodal disease in primary tumors < 2 cm, and some authors recommend appendectomy alone for all lesions under this threshold.[63],[64] In addition to size, histologic features influence surgical decision-making. Findings on histology that may be unfavorable include mesoappendiceal invasion >3 mm, advanced grade consisting of elevated mitotic index (>2 mitoses per high-power field) or Ki-67 index (>3%) and lymphatic or vascular invasion.[60],[65] Decision-making for right hemicolectomy in small- and intermediate-sized appendiceal NETs should be made on a case-by-case basis, with consideration given to histologic features and patient comorbidities and preferences.[60] Although the majority of appendiceal NETs occur in the tip of the appendix, patients with tumor present at the base of the appendix or those resected with a positive margin may need to undergo more extensive resection to obtain negative surgical margins.[63]

8. Surveillance after resection of appendiceal NETs with curative intent should involve physical examination, serial biochemical testing, and imaging of the chest, abdomen, and pelvis using either CT or MRI. Grade: Weak recommendation based on low-quality evidence, 2C.

For patients who have undergone surgical resection with curative intent, it is recommended that surveillance for disease recurrence be performed in patients deemed to be candidates for further treatment should a recurrence be detected. Surveillance involves clinical, biochemical, and radiographic components. Although the interval between surveillance evaluations and the duration of surveillance is not standardized because of the rarity and often indolent nature of NETs, the interval between surveillance examinations typically ranges from 6 to 12 months, depending on the histologic grade of NET, and it is generally recommended that the duration of surveillance extends for 10 years after curative resection.[66],[67] Serum chromogranin A levels and urine 5-hydroxyindoleacetic acid levels can correlate both with response to therapy and recurrence, but because of the nonspecific nature of these biomarkers, correlation with imaging studies is required.[68] Currently, there are insufficient data to support routine use of SRS or other NET-specific imaging modalities for routine surveillance, although they may be beneficial in confirming recurrent disease discovered on CT or MRI, as well as assessing somatostatin receptor expression for potential therapeutic consideration.[69],[70]

APPENDICEAL MUCINOUS NEOPLASMS AND ADENOCARCINOMA

9. Tumor markers typically should be assessed on diagnosis of appendiceal epithelial neoplasms and routinely followed after resection. Grade: Weak recommendation based on low-quality evidence, 2C.

The serum tumor markers CEA, CA19-9, and CA125 are frequently obtained on diagnosis of appendiceal mucinous neoplasms and routinely monitored to assess disease remission or progression.[71] Although their individual predictability of disease recurrence has not been well characterized, most high-volume institutions routinely combine tumor markers with imaging at baseline, during chemotherapy, and after surgery, if applicable. In the setting of mucinous adenocarcinoma of the appendix, a normal baseline CA-125 has been shown to correlate with the likelihood of achieving complete cytoreduction.[72] Elevated baseline CA19-9 has also been described as an independent predictor of worse progression-free survival (PFS) and can be useful to diagnose disease recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).[72],[73] CEA has been reported to normalize after complete cytoreduction, as compared with CA 19-9 and CA-125, which may remain elevated.[74] Taflampas et al[75] showed a significantly longer disease-specific survival in treated patients with normal preoperative markers, and they suggested that tumor marker elevation may help tailor the need for perioperative systemic chemotherapy. However, surveillance imaging seems more sensitive for detecting peritoneal disease recurrence than tumor markers alone.[76]

With regard to the use of other markers to distinguish low-grade versus HAMNs, many have proposed molecular profiling, including cyclooxygenase 2 expression and KRAS, TP53, and SMAD4 gene mutations, without conclusive evidence on their impact on diagnosis or management.[77],[78],[79],[80],[81] Although some generalizations may be extrapolated from colorectal cancer, the rarity of appendiceal adenocarcinoma limits the ability to make conclusions regarding specific genetic defects.

10. Cross-sectional imaging with CT or MRI should be performed on diagnosis of appendiceal epithelial neoplasms and routinely followed after resection. Grade: Strong recommendation based on low-quality evidence, 1C.

CT of the chest, abdomen, and pelvis is the most common imaging modality used to evaluate the primary tumor and assess for metastatic disease. The addition of a PET scan has not been shown to improve staging or significantly change management.[82] MRI can detect extraluminal mucin and has also been shown to be superior to CT in the detection of peritoneal disease using a combination of diffusion-weighted imaging and delayed postgadolinium sequences.[83] In small noncomparison studies, MRI has proven useful to predict the peritoneal cancer index (PCI) before surgery, and it is often used in postoperative surveillance after CRS and HIPEC.[76],[83] Unfortunately, accurate preoperative diagnosis can be challenging because of a wide range of clinical presentations and overlapping imaging appearances of appendiceal neoplasms. Although some have proposed using the 2010 World Health Organization pathologic classification as a framework to report imaging findings in patients with appendiceal neoplasms, no structured imaging reporting systems are routinely used in this patient population.[84]

Although there are no formal surveillance guidelines for appendiceal neoplasms after appendectomy, patients with low-grade localized tumors of the appendix who undergo appendectomy alone rarely develop PMP; therefore, frequent postoperative imaging for extended intervals is typically of minimal benefit.[6],[85],[86] Postoperative surveillance must be individualized in these situations according to tumor and patient characteristics. One approach for localized and completely resected LAMN is to obtain MRI with tumor markers every 6 months for 2 years because most early recurrences occur within that timeframe.[85] Patients with high-grade tumors or who undergo right hemicolectomy because of a locally advanced or perforated tumor, questionable surgical margins, or who had lymphatic or peritoneal disease should typically undergo CT or MRI every 4 to 6 months for the first 2 years and yearly thereafter for ≥5 years. In patients with acellular or low-grade peritoneal disease who have undergone CRS and HIPEC, CT or MRI of the abdomen and pelvis is recommended at 2 months postoperatively (baseline), then annually for ≥5 years.[86],[87] In patients with high-grade peritoneal disease, additional imaging of the chest and more frequent surveillance every 6 months for the first 6 years postoperatively may help detect recurrent disease earlier.[88] Although peritoneal recurrences beyond 10 years may occur and some institution-specific surveillance protocols may extend to 15 years, there is no clear evidence supporting prolonged surveillance.[89]

11. Peritoneal cytology has minimal impact on the management of patients with appendiceal tumors and is not recommended as routine practice. Grade: Weak recommendation based on low-quality evidence, 2C.

Although positive peritoneal cytology is useful to various degrees in patients with pancreatic, gastric, or ovarian malignancy, the use of cytology in patients with appendiceal neoplasms remains unknown.[90],[91],[92] Some insight may be gained from extrapolation of studies on colorectal cancer with peritoneal spread. Positive peritoneal cytology occurs in 23.5% of treated patients and correlates with OS (19 vs 44 mo for negative peritoneal cytology; p = 0.01).[93] Yonemura et al[94] also showed that positive cytology was independently associated with worse PFS in 205 patients with colorectal cancer undergoing complete CRS and HIPEC. Neither of these studies performed subgroup analysis for patients with appendiceal malignancies or evaluated its role in the decision to perform HIPEC. In patients with appendiceal neoplasms, there is no evidence to support the routine evaluation of peritoneal cytology, because its impact on management and prognosis remains unclear.

12. Patients with LAMNs with negative margins and no evidence of perforation or peritoneal involvement are safely treated with appendectomy alone. Grade of recommendation: Strong recommendation based on moderate-quality evidence, 1B.

In modern observational studies, oncologic outcomes after appendectomy, including the entire mesoappendix for LAMN without perforation or peritoneal involvement, have shown very low recurrence rates, consistent with the indolent behavior of these neoplasms.[95],[96],[97] Appropriate initial surgical management is critical because iatrogenic rupture of the appendix can convert the situation from localized to disseminated; therefore, if an unruptured LAMN cannot be safely resected laparoscopically, conversion to an open operation is recommended. Limited published data suggest that a microscopically positive resection margin after appendectomy for nonperforated LAMN does not predict disease recurrence and therefore does not warrant formal right colectomy.[98] Guaglio et al[85] prospectively examined 41 patients with LAMN treated by appendectomy (n = 31) or right colectomy (n = 5) with close radiographic and biochemical surveillance. Appendiceal rupture was present in 21 patients (51%). At a median follow-up of 58 months, 5-year recurrence-free survival was 95%, with only 2 patients experiencing peritoneal recurrences at 18 and 22 months postappendectomy.

Rarely, a primary appendiceal mucinous neoplasm will harbor high-grade cytology yet lack infiltrative invasion associated with adenocarcinoma. These lesions are best classified as HAMNs.[14] Although appendectomy alone is typically sufficient for treating HAMNs, care should be taken to exclude the presence of associated invasive adenocarcinoma, including comprehensive histologic evaluation of the entire surgical specimen.

13. Patients with nonmetastatic adenocarcinoma of the appendix should undergo right hemicolectomy. However, in the setting of peritoneal spread, colectomy may not confer a survival benefit. Grade: Strong recommendation based on low-quality evidence, 1C.

In patients with appendiceal adenocarcinoma, the rate of metastatic disease to regional lymph nodes ranges from 20% to 67%, with positive nodes more likely in the nonmucinous (intestinal) subtype.[99],[100],[101],[102],[103] Because of this substantial risk, adenocarcinoma confined to the appendix should be treated with right hemicolectomy, because formal resection of the nodal basin allows for more complete staging and may have a therapeutic benefit.[102] The recommendation for formal colectomy also includes appendiceal goblet cell carcinoids, tumors characterized by a mixture of histologic features of both neuroendocrine and epithelial adenocarcinoma.[104] The natural history of patients with goblet cell carcinoid of the appendix closely resembles high-grade appendiceal tumors, and it should be treated in a similar manner.[103],[105],[106],[107]

In the setting of peritoneal metastases, routine right hemicolectomy to remove clinically normal lymph nodes is not recommended. Several single-institution and retrospective observational studies have failed to demonstrate a survival benefit to right colectomy versus appendectomy alone in patients undergoing CRS and HIPEC.[100],[102],[108],[109] Turaga et al[102] examined population-based data using Surveillance, Epidemiology, and End Results and found that right colectomy did not improve survival after adjusting for age, sex, T stage, metastatic disease, and grade. Interestingly, no benefit to colectomy was seen in node-positive patients without peritoneal metastases either, suggesting that nodal positivity reflects a more aggressive biology that is not impacted by surgical resection. Despite these reservations, it should be noted that right colectomy is sometimes necessary to achieve a complete cytoreduction of peritoneal disease originating from the appendix.

14. CRS is indicated in selected patients with appendiceal neoplasms and evidence of peritoneal involvement. Grade: Strong recommendation based on moderate-quality evidence, 1B.

Surgical resection remains the benchmark therapy for patients with appendiceal neoplasms with peritoneal metastases. The goal of CRS is eradication of gross disease; when this goal is achieved, CRS is often combined with intraperitoneal chemotherapy, such as HIPEC (see subsequent recommendation). Typically, CRS entails selective peritonectomies, especially over the diaphragms and within the pelvis, excision or destruction of tumor implants on the surfaces of the small intestine and colon, supracolic omentectomy, and other resections as indicated by involvement (eg, splenectomy).[110],[111],[112] Individualized decisions regarding CRS with or without HIPEC should be undertaken by a multidisciplinary team, preferably at experienced centers.[109],[113] Proper patient selection is crucial in treating patients with peritoneal involvement from appendiceal neoplasms.[114] Findings on cross-sectional imaging may help determine resectability and guide selection of suitable candidates for cytoreduction.[115],[116] Diagnostic laparoscopy may also be used to estimate the likelihood of complete cytoreduction or to obtain tissue if other techniques such as CT-guided biopsy are not feasible. Peritoneal involvement may be quantified using Sugarbaker’s Peritoneal Carcinomatosis Index (PCI) or the Peritoneal Surface Disease Severity Score.[117],[118],[119] PCI is an intraoperative determination based on the size of tumor deposits in 13 regions within the abdomen and ranges from 0 to 39. The Peritoneal Surface Disease Severity Score incorporates clinical symptoms, PCI, and tumor histology to produce a maximum score of 22; stage IV is considered >10. Although useful for objectively measuring disease, such scoring systems may not correlate with survival in appendiceal neoplasms treated with complete cytoreduction.[110] However, successful cytoreduction is less likely in patients with biliary or ureteral obstruction, multifocal bowel obstruction, or extensive small bowel involvement. In almost every analysis of clinical and pathologic factors, completeness of cytoreduction is consistently an independent predictor of outcome.[13],[15],[110],[114],[120],[121],[122],[123],[124],[125],[126]

Women with peritoneal spread often experience ovarian involvement. Metastatic ovarian tumors may grow rapidly and typically are resistant to systemic chemotherapy. Mehta et al[127] retrospectively evaluated 258 female patients with ≥1 remaining ovary who underwent CRS and HIPEC for colorectal and appendiceal tumors. Overall, 141 of 258 patients (55%) had ovarian tumor involvement. Of 40 patients with 1 macroscopic ovarian metastasis, microscopic involvement of the contralateral ovary was found in 18 (45%) of 40. Of 141 patients in whom both ovaries were macroscopically normal, 24 (17%) of 141 had microscopic ovarian involvement. Given the risk of occult ovarian metastases in this patient population, bilateral salpingo-oophorectomy should be strongly considered, and patients should be appropriately counseled preoperatively.[128]

The management of patients with limited peritoneal involvement of acellular mucin in the setting of LAMN remains controversial, particularly when it is isolated to the right lower quadrant.[6],[86],[129] Appendectomy with cytoreduction of the periappendiceal peritoneum in these cases has been associated with reasonably low peritoneal recurrence rates between 3% and 7%. Conversely, LAMNs associated with cellular mucin deposits are associated with a higher risk of subsequent peritoneal involvement (33%–78%); these patients should be considered for HIPEC.[130],[131]

15. In selected patients with appendiceal epithelial neoplasms, intraperitoneal chemotherapy may offer additional benefit for reducing peritoneal disease recurrence compared with CRS alone. Grade: Strong recommendation based on moderate-quality evidence, 1B.

After complete resection of all gross peritoneal disease, patients with appendiceal neoplasms may be treated with intraperitoneal chemotherapy. Most commonly, this is performed concurrently with CRS through the delivery of HIPEC. Interest in CRS and HIPEC for appendiceal neoplasms increased after a large randomized, controlled trial for carcinomatosis from colorectal and appendiceal cancers demonstrated a doubling of survival for CRS/HIPEC compared with systemic chemotherapy alone (22.3- vs 12.6-mo median OS).[120] Additional long-term follow-up demonstrated a median OS of 48 months and a 5-year survival of 45% for those patients for whom a complete cytoreduction could be achieved.[132] Multiple large retrospective and prospective phase II studies including patients with both low-grade and high-grade peritoneal disease have demonstrated improved long-term patient survival, decreased tumor recurrence, longer time to disease progression, and less frequent repeat operative interventions in patients who undergo CRS plus HIPEC compared with debulking procedures alone or palliative systemic chemotherapy.[13],[15],[124],[133],[134],[135],[136],[137],[138],[139],[140],[141] A 2012 observational study by Chua et al[13] including 2298 patients reported superior PFS associated with HIPEC after CRS (HR = 0.65; p = 0.03) for metastatic appendiceal mucinous neoplasm, but there was no OS difference in their multivariate analysis.[142] Median OS was 16.3 years, and median PFS was 8.2 years. Mitomycin or platinum-based chemotherapeutics are the most common drugs used during HIPEC.

Aside from HIPEC, other methods for delivering intraperitoneal chemotherapy include the early postoperative intraperitoneal chemotherapy (EPIC) or delayed postoperative approaches.[16],[126],[143],[144],[145],[146],[147],[148],[149] Generally, similar results are obtained among the various approaches, and few head-to-head comparisons exist; a retrospective study in Norway of 93 patients compared EPIC and HIPEC after complete cytoreduction and showed no difference in 10-year OS and DFS.[16] An ongoing randomized, controlled trial of HIPEC versus EPIC may provide additional answers about which treatment is superior.[142]

16. Systemic chemotherapy may improve survival in patients with metastatic HAMNs. Benefit from systemic chemotherapy for low-grade lesions with peritoneal spread is questionable. Grade: Strong recommendation based on low-quality evidence, 1C.

The role of systemic chemotherapy and the optimal chemotherapeutic drug regimen for treatment of metastatic appendiceal malignancies continues to be investigated. Although lacking level I evidence, 5-fluorouracil–based systemic chemotherapy (similar to that used for colorectal adenocarcinoma) is typically recommended for patients with high-grade peritoneal disease or nodal metastases. Blackham et al[150] reported improved PFS with perioperative systemic chemotherapy in patients with high-grade PMP undergoing CRS plus HIPEC, especially in patients who underwent suboptimal cytoreduction and those with signet ring cell histology. Systemic chemotherapy showed no benefit in patients with low-grade disease. Bijelic et al[151] reported a 30% partial or complete tumor response in patients with high-grade PMP who received preoperative systemic chemotherapy and then underwent CRS plus HIPEC. This subgroup of patients demonstrated significantly longer OS when compared with patients with no tumor response (median not reached versus 29.5 mo in those without response; p = 0.03). Targeted therapy and preoperative noncytotoxic agents based on immunohistochemistry for cyclooxygenase 2 expression and KRAS mutational status have shown no significant impact on survival.[78] Conversely, systemic chemotherapy combined with bevacizumab has shown improved OS and PFS for unresectable high-grade appendiceal adenocarcinoma, and currently there is a prospective phase II trial evaluating the impact of adjuvant 5-fluorouracil–based chemotherapy with bevacizumab (clinicaltrials.gov NCT02420509).[152] Although the timing of perioperative systemic chemotherapy has shown conflicting results, as with other malignancies, there are several potential advantages of preoperative chemotherapy, including the ability to assess disease response and patient tolerance, administer upfront systemic therapy that would likely be indicated postoperatively in the majority of patients, and allow for as-yet-undeclared distant metastatic disease to appear on imaging and possibly preclude CRS of questionable benefit.[153]

References

  1. Marmor S, Portschy PR, Tuttle TM, et al. The rise in appendiceal cancer incidence: 2000-2009. J Gastrointest Surg. 2015;19(4):743-50.  [PMID:25560182]
  2. McCusker ME, Coté TR, Clegg LX, et al. Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998. Cancer. 2002;94(12):3307-12.  [PMID:12115365]
  3. Hanna M, Hwang G, Moghadamyeghaneh Z, et al. Incidental appendiceal cancer at appendectomy: an analysis of incidence, trends and risk factors. Dis Colon Rectum. 2015;58:E339.
  4. Overman MJ, Fournier K, Hu CY, et al. Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade. Ann Surg. 2013;257(6):1072-8.  [PMID:23001080]
  5. Smeenk RM, van Velthuysen ML, Verwaal VJ, et al. Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol. 2008;34(2):196-201.  [PMID:17524597]
  6. Tiselius C, Kindler C, Shetye J, et al. Computed Tomography Follow-Up Assessment of Patients with Low-Grade Appendiceal Mucinous Neoplasms: Evaluation of Risk for Pseudomyxoma Peritonei. Ann Surg Oncol. 2017;24(7):1778-1782.  [PMID:28474197]
  7. World Health Organization. WHO Classification of Tumours of the Digestive System. 2010.4th ed. Lyon, France: IARC Press.
  8. Fournier KF, Royal R, Lambert LA, et al. Mucinous appendiceal tumors of uncertain malignant potential (UMP): prognostic factors and implications for treatment and follow-up. J Clin Oncol. 2011;29:372.
  9. Carr NJ, Bibeau F, Bradley RF, et al. The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. Histopathology. 2017;71(6):847-858.  [PMID:28746986]
  10. Brathwaite S, Rock J, Yearsley MM, et al. Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity. Ann Surg Oncol. 2016;23(7):2281-6.  [PMID:26965701]
  11. Turaga KK, Pappas SG, Gamblin T. Importance of histologic subtype in the staging of appendiceal tumors. Ann Surg Oncol. 2012;19(5):1379-85.  [PMID:22302267]
  12. Cerame MA. A 25-year review of adenocarcinoma of the appendix. A frequently perforating carcinoma. Dis Colon Rectum. 1988;31(2):145-50.  [PMID:3276467]
  13. Chua TC, Moran BJ, Sugarbaker PH, et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30(20):2449-56.  [PMID:22614976]
  14. Carr NJ, Cecil TD, Mohamed F, et al. A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process. Am J Surg Pathol. 2016;40(1):14-26.  [PMID:26492181]
  15. Smeenk RM, Verwaal VJ, Antonini N, et al. Survival analysis of pseudomyxoma peritonei patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg. 2007;245(1):104-9.  [PMID:17197972]
  16. Sørensen O, Flatmark K, Reed W, et al. Evaluation of complete cytoreductive surgery and two intraperitoneal chemotherapy techniques in Pseudomyxoma peritonei. Eur J Surg Oncol. 2012;38(10):969-76.  [PMID:22763244]
  17. Davison JM, Choudry HA, Pingpank JF, et al. Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade. Mod Pathol. 2014;27(11):1521-39.  [PMID:24633196]
  18. Shetty S, Natarajan B, Thomas P, et al. Proposed classification of pseudomyxoma peritonei: influence of signet ring cells on survival. Am Surg. 2013;79(11):1171-6.  [PMID:24165252]
  19. Doede T, Foss HD, Waldschmidt J. Carcinoid tumors of the appendix in children--epidemiology, clinical aspects and procedure. Eur J Pediatr Surg. 2000;10(6):372-7.  [PMID:11215778]
  20. Moris D, Tsilimigras DI, Vagios S, et al. Neuroendocrine Neoplasms of the Appendix: A Review of the Literature. Anticancer Res. 2018;38(2):601-611.  [PMID:29374682]
  21. Sugarbaker PH. Epithelial appendiceal neoplasms. Cancer J. 2009;15(3):225-35.  [PMID:19556909]
  22. Shankar S, Ledakis P, El Halabi H, et al. Neoplasms of the appendix: current treatment guidelines. Hematol Oncol Clin North Am. 2012;26(6):1261-90.  [PMID:23116580]
  23. Lu P, McCarty JC, Fields AC, et al. Risk of appendiceal cancer in patients undergoing appendectomy for appendicitis in the era of increasing nonoperative management. J Surg Oncol. 2019;120(3):452-459.  [PMID:31270824]
  24. Loftus TJ, Raymond SL, Sarosi GA, et al. Predicting appendiceal tumors among patients with appendicitis. J Trauma Acute Care Surg. 2017;82(4):771-775.  [PMID:28099380]
  25. Schwartz JA, Forleiter C, Lee D, et al. Occult Appendiceal Neoplasms in Acute and Chronic Appendicitis: A Single-Institution Experience of 1793 Appendectomies. Am Surg. 2017;83(12):1381-1385.  [PMID:29336758]
  26. Wright GP, Mater ME, Carroll JT, et al. Is there truly an oncologic indication for interval appendectomy? Am J Surg. 2015;209(3):442-6.  [PMID:25543294]
  27. Mällinen J, Rautio T, Grönroos J, et al. Risk of Appendiceal Neoplasm in Periappendicular Abscess in Patients Treated With Interval Appendectomy vs Follow-up With Magnetic Resonance Imaging: 1-Year Outcomes of the Peri-Appendicitis Acuta Randomized Clinical Trial. JAMA Surg. 2019;154(3):200-207.  [PMID:30484824]
  28. Furman MJ, Cahan M, Cohen P, et al. Increased risk of mucinous neoplasm of the appendix in adults undergoing interval appendectomy. JAMA Surg. 2013;148(8):703-6.  [PMID:23740174]
  29. Lohsiriwat V, Vongjirad A, Lohsiriwat D. Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance. World J Surg Oncol. 2009;7:51.  [PMID:19490638]
  30. Trivedi AN, Levine EA, Mishra G. Adenocarcinoma of the appendix is rarely detected by colonoscopy. J Gastrointest Surg. 2009;13(4):668-75.  [PMID:19089515]
  31. Salemis NS, Nakos G, Katikaridis I, et al. Synchronous occurrence of appendiceal mucinous cystadenoma, with colon adenocarcinoma and tubulovillous rectal adenoma: Management and review of the literature. J Nat Sci Biol Med. 2016;7(2):173-5.  [PMID:27433069]
  32. Khan MN, Moran BJ. Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia. Dis Colon Rectum. 2007;50(11):1856-9.  [PMID:17763906]
  33. Song EM, Yang HJ, Lee HJ, et al. Endoscopic Resection of Cecal Polyps Involving the Appendiceal Orifice: A KASID Multicenter Study. Dig Dis Sci. 2017;62(11):3138-3148.  [PMID:28936593]
  34. Park KB, Park JS, Choi GS, et al. Single-incision Laparoscopic Surgery for Appendiceal Mucoceles: Safety and Feasibility in a Series of 16 Consecutive Cases. J Korean Soc Coloproctol. 2011;27(6):287-92.  [PMID:22259743]
  35. Bucher P, Gervaz P, Ris F, et al. Laparoscopic versus open resection for appendix carcinoid. Surg Endosc. 2006;20(6):967-70.  [PMID:16738993]
  36. Shindholimath VV, Thinakaran K, Rao TN, et al. Laparoscopic management of appendicular mass. J Minim Access Surg. 2011;7(2):136-40.  [PMID:21523236]
  37. Park KJ, Choi HJ, Kim SH. Laparoscopic approach to mucocele of appendiceal mucinous cystadenoma: feasibility and short-term outcomes in 24 consecutive cases. Surg Endosc. 2015;29(11):3179-83.  [PMID:25582961]
  38. Cheng A, Li M, Kanis MJ, et al. Is it necessary to perform routine appendectomy for mucinous ovarian neoplasms? A retrospective study and meta-analysis. Gynecol Oncol. 2017;144(1):215-222.  [PMID:27889016]
  39. Kleppe M, Bruls J, Van Gorp T, et al. Mucinous borderline tumours of the ovary and the appendix: a retrospective study and overview of the literature. Gynecol Oncol. 2014;133(2):155-8.  [PMID:24552756]
  40. Feigenberg T, Covens A, Ghorab Z, et al. Is routine appendectomy at the time of primary surgery for mucinous ovarian neoplasms beneficial? Int J Gynecol Cancer. 2013;23(7):1205-9.  [PMID:23835504]
  41. Burke AP, Thomas RM, Elsayed AM, et al. Carcinoids of the jejunum and ileum: an immunohistochemical and clinicopathologic study of 167 cases. Cancer. 1997;79(6):1086-93.  [PMID:9070484]
  42. Janson ET, Holmberg L, Stridsberg M, et al. Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol. 1997;8(7):685-90.  [PMID:9296223]
  43. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97(4):934-59.  [PMID:12569593]
  44. Saha S, Hoda S, Godfrey R, et al. Carcinoid tumors of the gastrointestinal tract: a 44-year experience. South Med J. 1989;82(12):1501-5.  [PMID:2595419]
  45. Marshall JB, Bodnarchuk G. Carcinoid tumors of the gut. Our experience over three decades and review of the literature. J Clin Gastroenterol. 1993;16(2):123-9.  [PMID:8463615]
  46. Bolanowski M, Bednarczuk T, Bobek-Billewicz B, et al. Neuroendocrine neoplasms of the small intestine and the appendix - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol. 2013;64(6):480-93.  [PMID:24431119]
  47. Nikou GC, Lygidakis NJ, Toubanakis C, et al. Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues. Hepatogastroenterology. 2005;52(63):731-41.  [PMID:15966194]
  48. Reubi JC, Laissue J, Waser B, et al. Expression of somatostatin receptors in normal, inflamed, and neoplastic human gastrointestinal tissues. Ann N Y Acad Sci. 1994;733:122-37.  [PMID:7978860]
  49. Squires MH, Volkan Adsay N, Schuster DM, et al. Octreoscan Versus FDG-PET for Neuroendocrine Tumor Staging: A Biological Approach. Ann Surg Oncol. 2015;22(7):2295-301.  [PMID:25786743]
  50. Deppen SA, Liu E, Blume JD, et al. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. J Nucl Med. 2016;57(5):708-14.  [PMID:26769865]
  51. Sadowski SM, Neychev V, Millo C, et al. Prospective Study of 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography for Detecting Gastro-Entero-Pancreatic Neuroendocrine Tumors and Unknown Primary Sites. J Clin Oncol. 2016;34(6):588-96.  [PMID:26712231]
  52. Di Giacinto P, Rota F, Rizza L, et al. Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors. Int J Endocrinol. 2018;2018:8126087.  [PMID:30057604]
  53. Yao JC, Phan AT, Chang DZ, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study. J Clin Oncol. 2008;26(26):4311-8.  [PMID:18779618]
  54. Oberg K, Modlin IM, De Herder W, et al. Consensus on biomarkers for neuroendocrine tumour disease. Lancet Oncol. 2015;16(9):e435-e446.  [PMID:26370353]
  55. Campana D, Nori F, Piscitelli L, et al. Chromogranin A: is it a useful marker of neuroendocrine tumors? J Clin Oncol. 2007;25(15):1967-73.  [PMID:17513802]
  56. Mullen JT, Savarese DM. Carcinoid tumors of the appendix: a population-based study. J Surg Oncol. 2011;104(1):41-4.  [PMID:21294132]
  57. Shapiro R, Eldar S, Sadot E, et al. Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg. 2011;201(6):805-8.  [PMID:21741512]
  58. Fornaro R, Frascio M, Sticchi C, et al. Appendectomy or right hemicolectomy in the treatment of appendiceal carcinoid tumors? Tumori. 2007;93(6):587-90.  [PMID:18338494]
  59. Hsu C, Rashid A, Xing Y, et al. Varying malignant potential of appendiceal neuroendocrine tumors: importance of histologic subtype. J Surg Oncol. 2013;107(2):136-43.  [PMID:22767417]
  60. Pape UF, Niederle B, Costa F, et al. ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas). Neuroendocrinology. 2016;103(2):144-52.  [PMID:26730583]
  61. In't Hof KH, van der Wal HC, Kazemier G, et al. Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg. 2008;12(8):1436-8.  [PMID:18521695]
  62. Ciarrocchi A, Pietroletti R, Carlei F, et al. Clinical Significance of Metastatic Lymph Nodes in the Gut of Patients with Pure and Mixed Primary Appendiceal Carcinoids. Dis Colon Rectum. 2016;59(6):508-12.  [PMID:27145307]
  63. Moertel CG, Weiland LH, Nagorney DM, et al. Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med. 1987;317(27):1699-701.  [PMID:3696178]
  64. Nussbaum DP, Speicher PJ, Gulack BC, et al. Management of 1- to 2-cm Carcinoid Tumors of the Appendix: Using the National Cancer Data Base to Address Controversies in General Surgery. J Am Coll Surg. 2015;220(5):894-903.  [PMID:25840530]
  65. Volante M, Daniele L, Asioli S, et al. Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases. Am J Surg Pathol. 2013;37(4):606-12.  [PMID:23426123]
  66. Murray SE, Lloyd RV, Sippel RS, et al. Postoperative surveillance of small appendiceal carcinoid tumors. Am J Surg. 2014;207(3):342-5; discussion 345.  [PMID:24393285]
  67. Singh S, Moody L, Chan DL, et al. Follow-up Recommendations for Completely Resected Gastroenteropancreatic Neuroendocrine Tumors. JAMA Oncol. 2018;4(11):1597-1604.  [PMID:30054622]
  68. Plöckinger U, Couvelard A, Falconi M, et al. Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology. 2008;87(1):20-30.  [PMID:17934252]
  69. Maroun J, Kocha W, Kvols L, et al. Guidelines for the diagnosis and management of carcinoid tumours. Part 1: the gastrointestinal tract. A statement from a Canadian National Carcinoid Expert Group. Curr Oncol. 2006;13(2):67-76.  [PMID:17576444]
  70. Frilling A, Malago M, Martin H, et al. Use of somatostatin receptor scintigraphy to image extrahepatic metastases of neuroendocrine tumors. Surgery. 1998;124(6):1000-4.  [PMID:9854575]
  71. Munoz-Zuluaga CA, Sardi A, MacDonald R, et al. The role of preoperative tumor markers in patients with peritoneal carcinomatosis from appendiceal cancer undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2018;25:S155–S6.
  72. van Ruth S, Hart AA, Bonfrer JM, et al. Prognostic value of baseline and serial carcinoembryonic antigen and carbohydrate antigen 19.9 measurements in patients with pseudomyxoma peritonei treated with cytoreduction and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2002;9(10):961-7.  [PMID:12464587]
  73. Di Fabio F, Aston W, Mohamed F, et al. Elevated tumour markers are normalized in most patients with pseudomyxoma peritonei 7 days after complete tumour removal. Colorectal Dis. 2015;17(8):698-703.  [PMID:25704482]
  74. Baratti D, Kusamura S, Martinetti A, et al. Prognostic value of circulating tumor markers in patients with pseudomyxoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2007;14(8):2300-8.  [PMID:17510772]
  75. Taflampas P, Dayal S, Chandrakumaran K, et al. Pre-operative tumour marker status predicts recurrence and survival after complete cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal Pseudomyxoma Peritonei: Analysis of 519 patients. Eur J Surg Oncol. 2014;40(5):515-520.  [PMID:24462284]
  76. Low RN, Barone RM, Lee MJ. Surveillance MR imaging is superior to serum tumor markers for detecting early tumor recurrence in patients with appendiceal cancer treated with surgical cytoreduction and HIPEC. Ann Surg Oncol. 2013;20(4):1074-81.  [PMID:23456382]
  77. Szych C, Staebler A, Connolly DC, et al. Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women. Am J Pathol. 1999;154(6):1849-55.  [PMID:10362811]
  78. Raghav KP, Shetty AV, Kazmi SM, et al. Impact of molecular alterations and targeted therapy in appendiceal adenocarcinomas. Oncologist. 2013;18(12):1270-7.  [PMID:24149137]
  79. Goldstein DA, Elvin JA, Wang K, et al. Comprehensive genomic profiling of cancer of the appendix to reveal new routes to targeted therapies. J Clin Oncol. 2015;33:608.
  80. Levine EA, Votanopoulos KI, Qasem SA, et al. Prognostic Molecular Subtypes of Low-Grade Cancer of the Appendix. J Am Coll Surg. 2016;222(4):493-503.  [PMID:26821970]
  81. Davison JM, Hartman DA, Singhi AD, et al. Loss of SMAD4 protein expression is associated with high tumor grade and poor prognosis in disseminated appendiceal mucinous neoplasms. Am J Surg Pathol. 2014;38(5):583-92.  [PMID:24618609]
  82. Rohani P, Scotti SD, Shen P, et al. Use of FDG-PET imaging for patients with disseminated cancer of the appendix. Am Surg. 2010;76(12):1338-44.  [PMID:21265346]
  83. Low RN, Barone RM, Lucero J. Comparison of MRI and CT for predicting the Peritoneal Cancer Index (PCI) preoperatively in patients being considered for cytoreductive surgical procedures. Ann Surg Oncol. 2015;22(5):1708-15.  [PMID:25201499]
  84. Low RN, Barone RM. Combined diffusion-weighted and gadolinium-enhanced MRI can accurately predict the peritoneal cancer index preoperatively in patients being considered for cytoreductive surgical procedures. Ann Surg Oncol. 2012;19(5):1394-1401.  [PMID:22302265]
  85. Guaglio M, Sinukumar S, Kusamura S, et al. Clinical Surveillance After Macroscopically Complete Surgery for Low-Grade Appendiceal Mucinous Neoplasms (LAMN) with or Without Limited Peritoneal Spread: Long-Term Results in a Prospective Series. Ann Surg Oncol. 2018;25(4):878-884.  [PMID:29270877]
  86. Roxburgh CS, Fenig YM, Cercek A, et al. Outcomes of Low-Grade Appendiceal Mucinous Neoplasms with Remote Acellular Mucinous Peritoneal Deposits. Ann Surg Oncol. 2019;26(1):118-124.  [PMID:30421044]
  87. Van Hooser A, Williams TR, Myers DT. Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. Abdom Radiol (NY). 2018;43(11):2913-2922.  [PMID:29564494]
  88. Govaerts K, Chandrakumaran K, Carr NJ, et al. Single centre guidelines for radiological follow-up based on 775 patients treated by cytoreductive surgery and HIPEC for appendiceal pseudomyxoma peritonei. Eur J Surg Oncol. 2018;44(9):1371-1377.  [PMID:30017331]
  89. Choudry HA, Pai RK. Management of Mucinous Appendiceal Tumors. Ann Surg Oncol. 2018;25(8):2135-2144.  [PMID:29717422]
  90. Endo S, Ikenaga M, Ohta K, et al. Prognostic factors for cytology-positive gastric cancer. Surg Today. 2019;49(1):56-64.  [PMID:30167924]
  91. Jimenez RE, Warshaw AL, Fernandez-Del Castillo C. Laparoscopy and peritoneal cytology in the staging of pancreatic cancer. J Hepatobiliary Pancreat Surg. 2000;7(1):15-20.  [PMID:10982586]
  92. Zuna RE, Behrens A. Peritoneal washing cytology in gynecologic cancers: long-term follow-up of 355 patients. J Natl Cancer Inst. 1996;88(14):980-7.  [PMID:8667429]
  93. Trilling B, Cotte E, Vaudoyer D, et al. Intraperitoneal-Free Cancer Cells Represent a Major Prognostic Factor in Colorectal Peritoneal Carcinomatosis. Dis Colon Rectum. 2016;59(7):615-22.  [PMID:27270513]
  94. Yonemura Y, Canbay E, Shintani H, et al. Treatment Failure Following Complete Cytoreductive Surgery for Peritoneal Metastasis from Colorectal Cancer. Gan To Kagaku Ryoho. 2016;43(12):1435-1439.  [PMID:28133015]
  95. Fournier K, Rafeeq S, Taggart M, et al. Low-grade Appendiceal Mucinous Neoplasm of Uncertain Malignant Potential (LAMN-UMP): Prognostic Factors and Implications for Treatment and Follow-up. Ann Surg Oncol. 2017;24(1):187-193.  [PMID:27660258]
  96. Morano WF, Gleeson EM, Sullivan SH, et al. Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review. Am Surg. 2018;84(2):273-281.  [PMID:29580358]
  97. Li X, Zhou J, Dong M, et al. Management and prognosis of low-grade appendiceal mucinous neoplasms: A clinicopathologic analysis of 50 cases. Eur J Surg Oncol. 2018;44(10):1640-1645.  [PMID:30100360]
  98. Arnason T, Kamionek M, Yang M, et al. Significance of proximal margin involvement in low-grade appendiceal mucinous neoplasms. Arch Pathol Lab Med. 2015;139(4):518-21.  [PMID:24971927]
  99. Benedix F, Reimer A, Gastinger I, et al. Primary appendiceal carcinoma--epidemiology, surgery and survival: results of a German multi-center study. Eur J Surg Oncol. 2010;36(8):763-71.  [PMID:20561765]
  100. González-Moreno S, Sugarbaker PH. Right hemicolectomy does not confer a survival advantage in patients with mucinous carcinoma of the appendix and peritoneal seeding. Br J Surg. 2004;91(3):304-11.  [PMID:14991630]
  101. Sugarbaker PH. When and When Not to Perform a Right Colon Resection with Mucinous Appendiceal Neoplasms. Ann Surg Oncol. 2017;24(3):729-732.  [PMID:27770344]
  102. Turaga KK, Pappas S, Gamblin TC. Right hemicolectomy for mucinous adenocarcinoma of the appendix: just right or too much? Ann Surg Oncol. 2013;20(4):1063-7.  [PMID:23456377]
  103. Nash GM, Smith JD, Tang L, et al. Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review. Ann Surg Oncol. 2015;22(11):3613-7.  [PMID:25663593]
  104. Rossi RE, Luong TV, Caplin ME, et al. Goblet cell appendiceal tumors--management dilemmas and long-term outcomes. Surg Oncol. 2015;24(1):47-53.  [PMID:25686643]
  105. McConnell YJ, Mack LA, Gui X, et al. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: an emerging treatment option for advanced goblet cell tumors of the appendix. Ann Surg Oncol. 2014;21(6):1975-82.  [PMID:24398544]
  106. Madsen AH, Ladekarl M, Villadsen GE, et al. Effects of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Goblet Cell Carcinoma: A Prospective Cohort Study. Ann Surg Oncol. 2018;25(2):422-430.  [PMID:29214450]
  107. Randle RW, Griffith KF, Fino NF, et al. Appendiceal goblet cell carcinomatosis treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Surg Res. 2015;196(2):229-34.  [PMID:25881787]
  108. Foster JM, Gupta PK, Carreau JH, et al. Right hemicolectomy is not routinely indicated in pseudomyxoma peritonei. Am Surg. 2012;78(2):171-7.  [PMID:22369825]
  109. Milovanov V, Sardi A, Aydin N, et al. Extensive surgical history prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is associated with poor survival outcomes in patients with peritoneal mucinous carcinomatosis of appendiceal origin. Eur J Surg Oncol. 2015;41(7):881-5.  [PMID:25899982]
  110. Votanopoulos KI, Bartlett D, Moran B, et al. PCI is Not Predictive of Survival After Complete CRS/HIPEC in Peritoneal Dissemination from High-Grade Appendiceal Primaries. Ann Surg Oncol. 2018;25(3):674-678.  [PMID:29288288]
  111. Sugarbaker PH, Bijelic L. The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. Tumori. 2008;94(5):694-700.  [PMID:19112943]
  112. Sugarbaker PH. Cytoreductive surgery and perioperative intraperitoneal chemotherapy: a new standard of care for appendiceal mucinous tumors with peritoneal dissemination. Clin Colon Rectal Surg. 2005;18(3):204-14.  [PMID:20011303]
  113. Sneider EA, Shah S, Lambert L. Mucinous neoplasms of the appendix: A plea for early referral to a high volume center. Dis Colon Rectum. 2012;55:e205.
  114. Tabrizian P, Jibara G, Shrager B, et al. Outcomes for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the elderly. Surg Oncol. 2013;22(3):184-9.  [PMID:23827047]
  115. Bouquot M, Dohan A, Gayat E, et al. Prediction of Resectability in Pseudomyxoma Peritonei with a New CT Score. Ann Surg Oncol. 2018;25(3):694-701.  [PMID:29192372]
  116. Menassel B, Duclos A, Passot G, et al. Preoperative CT and MRI prediction of non-resectability in patients treated for pseudomyxoma peritonei from mucinous appendiceal neoplasms. Eur J Surg Oncol. 2016;42(4):558-66.  [PMID:26856956]
  117. Esquivel J, Garcia SS, Hicken W, et al. Evaluation of a new staging classification and a Peritoneal Surface Disease Severity Score (PSDSS) in 229 patients with mucinous appendiceal neoplasms with or without peritoneal dissemination. J Surg Oncol. 2014;110(6):656-60.  [PMID:24898451]
  118. Yoon W, Alame A, Berri R. Peritoneal Surface Disease Severity Score as a predictor of resectability in the treatment of peritoneal surface malignancies. Am J Surg. 2014;207(3):403-7; discussion 406-7.  [PMID:24444858]
  119. Jacquet P, Sugarbaker PH. Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res. 1996;82:359-74.  [PMID:8849962]
  120. Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 2003;21(20):3737-43.  [PMID:14551293]
  121. Van Sweringen HL, Hanseman DJ, Ahmad SA, et al. Predictors of survival in patients with high-grade peritoneal metastases undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Surgery. 2012;152(4):617-24; discussion 624-5.  [PMID:22943843]
  122. Reghunathan M, Kelly KJ, Valasek MA, et al. Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Ann Surg Oncol. 2018;25(3):702-708.  [PMID:29282599]
  123. Levine EA, Stewart JH, Shen P, et al. Intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1,000 patients. J Am Coll Surg. 2014;218(4):573-85.  [PMID:24491244]
  124. Elias D, Glehen O, Pocard M, et al. A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix. Ann Surg. 2010;251(5):896-901.  [PMID:20395843]
  125. Jimenez W, Sardi A, Nieroda C, et al. Predictive and prognostic survival factors in peritoneal carcinomatosis from appendiceal cancer after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2014;21(13):4218-25.  [PMID:24986239]
  126. Culliford AT, Brooks AD, Sharma S, et al. Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. Ann Surg Oncol. 2001;8(10):787-95.  [PMID:11776492]
  127. Mehta AM, Bignell MB, Alves S, et al. Risk of Ovarian Involvement in Advanced Colorectal or Appendiceal Tumors Involving the Peritoneum. Dis Colon Rectum. 2017;60(7):691-696.  [PMID:28594718]
  128. Evers DJ, Verwaal VJ. Indication for oophorectomy during cytoreduction for intraperitoneal metastatic spread of colorectal or appendiceal origin. Br J Surg. 2011;98(2):287-92.  [PMID:21046680]
  129. Zih FS, Wong-Chong N, Hummel C, et al. Mucinous tumor of the appendix with limited peritoneal spread: is there a role for expectant observation? Ann Surg Oncol. 2014;21(1):225-31.  [PMID:24100959]
  130. Pai RK, Beck AH, Norton JA, et al. Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol. 2009;33(10):1425-39.  [PMID:19641451]
  131. Yantiss RK, Shia J, Klimstra DS, et al. Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol. 2009;33(2):248-55.  [PMID:18852679]
  132. Verwaal VJ, Bruin S, Boot H, et al. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15(9):2426-32.  [PMID:18521686]
  133. Yan TD, Links M, Xu ZY, et al. Cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms. Br J Surg. 2006;93(10):1270-6.  [PMID:16838392]
  134. Chua TC, Martin S, Saxena A, et al. Evaluation of the cost-effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (peritonectomy) at the St George Hospital peritoneal surface malignancy program. Ann Surg. 2010;251(2):323-9.  [PMID:20040853]
  135. El Halabi H, Gushchin V, Francis J, et al. The role of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) in patients with high-grade appendiceal carcinoma and extensive peritoneal carcinomatosis. Ann Surg Oncol. 2012;19(1):110-4.  [PMID:21701929]
  136. Polanco PM, Ding Y, Knox JM, et al. Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Patients with High-Grade, High-Volume Disseminated Mucinous Appendiceal Neoplasms. Ann Surg Oncol. 2016;23(2):382-90.  [PMID:26429720]
  137. Elias D, Honoré C, Ciuchendéa R, et al. Peritoneal pseudomyxoma: results of a systematic policy of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Br J Surg. 2008;95(9):1164-71.  [PMID:18690633]
  138. McDonald JR, O'Dwyer ST, Rout S, et al. Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms. Br J Surg. 2012;99(7):987-92.  [PMID:22517234]
  139. Mehta A, Mittal R, Chandrakumaran K, et al. Peritoneal Involvement Is More Common Than Nodal Involvement in Patients With High-Grade Appendix Tumors Who Are Undergoing Prophylactic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Dis Colon Rectum. 2017;60(11):1155-1161.  [PMID:28991079]
  140. Youssef H, Newman C, Chandrakumaran K, et al. Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum. 2011;54(3):293-9.  [PMID:21304299]
  141. Dayal S, Taflampas P, Riss S, et al. Complete cytoreduction for pseudomyxoma peritonei is optimal but maximal tumor debulking may be beneficial in patients in whom complete tumor removal cannot be achieved. Dis Colon Rectum. 2013;56(12):1366-72.  [PMID:24201390]
  142. Dehal A, Smith JJ, Nash GM. Cytoreductive surgery and intraperitoneal chemotherapy: an evidence-based review-past, present and future. J Gastrointest Oncol. 2016;7(1):143-57.  [PMID:26941992]
  143. Fajardo AD, Tan B, Reddy R, et al. Delayed repeated intraperitoneal chemotherapy after cytoreductive surgery for colorectal and appendiceal carcinomatosis. Dis Colon Rectum. 2012;55(10):1044-52.  [PMID:22965403]
  144. Huang Y, Alzahrani NA, Liauw W, et al. Early postoperative intraperitoneal chemotherapy is associated with survival benefit for appendiceal adenocarcinoma with peritoneal dissemination. Eur J Surg Oncol. 2017;43(12):2292-2298.  [PMID:29017824]
  145. Lam JY, McConnell YJ, Rivard JD, et al. Hyperthermic intraperitoneal chemotherapy + early postoperative intraperitoneal chemotherapy versus hyperthermic intraperitoneal chemotherapy alone: assessment of survival outcomes for colorectal and high-grade appendiceal peritoneal carcinomatosis. Am J Surg. 2015;210(3):424-30.  [PMID:26051744]
  146. Huang Y, Alzahrani NA, Liauw W, et al. Early Postoperative Intraperitoneal Chemotherapy for Low-Grade Appendiceal Mucinous Neoplasms with Pseudomyxoma Peritonei: Is it Beneficial? Ann Surg Oncol. 2017;24(1):176-183.  [PMID:27718032]
  147. Wagner PL, Jones D, Aronova A, et al. Multi-cycle early post-operative intraperitoneal chemotherapy (EPIC) following cytoreductive surgery for appendiceal neoplasms with isolated peritoneal metastasis. Ann Surg Oncol. 2010;17:S86.
  148. Lemoine L, Sugarbaker P, Van der Speeten K. Drugs, doses, and durations of intraperitoneal chemotherapy: standardising HIPEC and EPIC for colorectal, appendiceal, gastric, ovarian peritoneal surface malignancies and peritoneal mesothelioma. Int J Hyperthermia. 2017;33(5):582-592.  [PMID:28540826]
  149. Wagner PL, Jones D, Aronova A, et al. Early postoperative intraperitoneal chemotherapy following cytoreductive surgery for appendiceal mucinous neoplasms with isolated peritoneal metastasis. Dis Colon Rectum. 2012;55(4):407-15.  [PMID:22426264]
  150. Blackham AU, Swett K, Eng C, et al. Perioperative systemic chemotherapy for appendiceal mucinous carcinoma peritonei treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Surg Oncol. 2014;109(7):740-5.  [PMID:24375188]
  151. Bijelic L, Kumar AS, Stuart OA, et al. Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. Gastroenterol Res Pract. 2012;2012:163284.  [PMID:22899903]
  152. Choe JH, Overman MJ, Fournier KF, et al. Improved Survival with Anti-VEGF Therapy in the Treatment of Unresectable Appendiceal Epithelial Neoplasms. Ann Surg Oncol. 2015;22(8):2578-84.  [PMID:25582740]
  153. Milovanov V, Sardi A, Ledakis P, et al. Systemic chemotherapy (SC) before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in patients with peritoneal mucinous carcinomatosis of appendiceal origin (PMCA). Eur J Surg Oncol. 2015;41(5):707-12.  [PMID:25633641]
Last updated: December 8, 2022