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Fundamentals of Rectal Cancer SurgeryFundamentals of Rectal Cancer Surgery

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Rectal Cancer Pathology Assessment

Rectal Cancer Pathology Assessment is a topic covered in the Fundamentals of Rectal Cancer Surgery.

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-- The first section of this topic is shown below --

Staging

The preferred staging system (Tables 1 & 2) for rectal cancer is the TNM staging system proposed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). This system consists of three categories: 1) tumor (T), which denotes the depth of mural invasion; 2) nodal involvement (N), and, 3) distant metastasis (M). The combination of these categories based on clinical and/or pathologic data dictates the stage and this best correlates with the patient’s overall prognosis.

Table 1
Descriptive text is not available for this image
AJCC TNM Staging Definitions for Rectal Cancer (8th edition).
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging System.
Table 2
Descriptive text is not available for this image
AJCC Prognositic Stage Groupings for Rectal Cancer (8th edition)
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging System.

A key feature of rectal cancer staging is the importance of clinical stage in determining treatment recommendations. The Clinical TNM classification (cTNM) is usually performed during initial evaluation of the patient, using staging CT and rectal cancer MRI scans. Pathologic stage is only known after surgery, and is often lower than the clinical stage, due to downstaging caused by neoadjuvant therapy. The symbol “p” refers to the pathologic classification of the TNM, and is based on gross and histologic examination of endoscopic or surgical specimens. pT requires examination of the primary malignancy to assess the depth of mural invasion. pN requires resection or biopsy of nodal tissue, just as pM requires histologic examination of lesions in distant organs.

Modifiers to TNM classifications do not affect the stage grouping, though they alert physicians to clinical features important to assessing cancer stage. The “y” prefix indicates specimens assessed during or following neoadjuvant therapy; the cTNM or pTNM category is thus modified by a “y” prefix. The “r” prefix represents a recurrent tumor when staged after a documented disease-free interval. The “m” suffix refers to the presence of multiple primary tumors in a single specimen and is recorded in parentheses (such as pT(m)NM).

Pathologic analysis of the proctectomy specimen provides the basis for the pathologic stage. The College of American Pathologists (CAP) has provided a list of minimum reporting for each rectal cancer resection that extends beyond the TNM stage of the tumor. Further, it is the pathologist’s responsibility to grade the quality of mesorectal excision, which is an important surrogate for the measure of the quality of surgical resection.

-- To view the remaining sections of this topic, please log in or purchase a subscription --

Staging

The preferred staging system (Tables 1 & 2) for rectal cancer is the TNM staging system proposed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC). This system consists of three categories: 1) tumor (T), which denotes the depth of mural invasion; 2) nodal involvement (N), and, 3) distant metastasis (M). The combination of these categories based on clinical and/or pathologic data dictates the stage and this best correlates with the patient’s overall prognosis.

Table 1
Descriptive text is not available for this image
AJCC TNM Staging Definitions for Rectal Cancer (8th edition).
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging System.
Table 2
Descriptive text is not available for this image
AJCC Prognositic Stage Groupings for Rectal Cancer (8th edition)
Used with permission of the American College of Surgeons, Chicago, Illinois. The original source for this information is the AJCC Cancer Staging System.

A key feature of rectal cancer staging is the importance of clinical stage in determining treatment recommendations. The Clinical TNM classification (cTNM) is usually performed during initial evaluation of the patient, using staging CT and rectal cancer MRI scans. Pathologic stage is only known after surgery, and is often lower than the clinical stage, due to downstaging caused by neoadjuvant therapy. The symbol “p” refers to the pathologic classification of the TNM, and is based on gross and histologic examination of endoscopic or surgical specimens. pT requires examination of the primary malignancy to assess the depth of mural invasion. pN requires resection or biopsy of nodal tissue, just as pM requires histologic examination of lesions in distant organs.

Modifiers to TNM classifications do not affect the stage grouping, though they alert physicians to clinical features important to assessing cancer stage. The “y” prefix indicates specimens assessed during or following neoadjuvant therapy; the cTNM or pTNM category is thus modified by a “y” prefix. The “r” prefix represents a recurrent tumor when staged after a documented disease-free interval. The “m” suffix refers to the presence of multiple primary tumors in a single specimen and is recorded in parentheses (such as pT(m)NM).

Pathologic analysis of the proctectomy specimen provides the basis for the pathologic stage. The College of American Pathologists (CAP) has provided a list of minimum reporting for each rectal cancer resection that extends beyond the TNM stage of the tumor. Further, it is the pathologist’s responsibility to grade the quality of mesorectal excision, which is an important surrogate for the measure of the quality of surgical resection.

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Last updated: November 23, 2021

Citation

"Rectal Cancer Pathology Assessment." Fundamentals of Rectal Cancer Surgery, 2021. ASCRS U, www.ascrsu.com/ascrs/view/Fundamentals-of-Rectal-Cancer-Surgery/2831023/all/Rectal Cancer Pathology Assessment.
Rectal Cancer Pathology Assessment. Fundamentals of Rectal Cancer Surgery. 2021. https://www.ascrsu.com/ascrs/view/Fundamentals-of-Rectal-Cancer-Surgery/2831023/all/Rectal Cancer Pathology Assessment. Accessed March 21, 2023.
Rectal Cancer Pathology Assessment. (2021). In Fundamentals of Rectal Cancer Surgery https://www.ascrsu.com/ascrs/view/Fundamentals-of-Rectal-Cancer-Surgery/2831023/all/Rectal Cancer Pathology Assessment
Rectal Cancer Pathology Assessment [Internet]. In: Fundamentals of Rectal Cancer Surgery. ; 2021. [cited 2023 March 21]. Available from: https://www.ascrsu.com/ascrs/view/Fundamentals-of-Rectal-Cancer-Surgery/2831023/all/Rectal Cancer Pathology Assessment.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Rectal Cancer Pathology Assessment ID - 2831023 Y1 - 2021/11/23/ BT - Fundamentals of Rectal Cancer Surgery UR - https://www.ascrsu.com/ascrs/view/Fundamentals-of-Rectal-Cancer-Surgery/2831023/all/Rectal Cancer Pathology Assessment DB - ASCRS U DP - Unbound Medicine ER -
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Grapherence® [↑30]
    • Fundamentals of Rectal Cancer Surgery
    • Background
    • Rectal Anatomy
    • Rectal Cancer Biology and Hereditary Cancer Syndromes
    • Rationale for Multi-Modality Therapy
    • Preoperative Issues
    • Preoperative Staging
    • Role of Tumor Board
    • Indications for Preoperative Neoadjuvant Therapy
    • Local Excision
    • Indications for LAR Versus Intersphincteric Resection Versus APR
    • Indications for Extended Resection
    • Preoperative Preparation
    • Interoperative
    • Patient Positioning and Equipment for Rectal Cancer Surgery
    • Inferior Mesenteric Artery
    • Inferior Mesenteric Vein (IMV)
    • Splenic Flexure Mobilization
    • Surgical Techniques for Length
    • Technique of Total Mesorectal Excision (TME)
    • Tailored Mesorectal Excision (TME)
    • Bowel Transection and Anastomosis
    • Indications for Fecal Diversion
    • Abdominoperineal Resection
    • Standardized Operative Report
    • Management of Intraoperative Vascular and Urinary Complications
    • Postoperative Issues
    • Rectal Cancer Pathology Assessment
    • Adjuvant Therapy for Rectal Adenocarcinoma
    • Surveillance After Rectal Cancer Treatment
    • Management of Local Recurrences
    • Short-Term Complications - Anastomotic
    • Short-Term Complications - Urinary
    • Ostomy Complications and Management
    • Long-Term Complications – Bowel Dysfunction
    • Long-Term Complications - Sexual Dysfunction and Its Management
    • Parastomal and Perineal Hernias
    • Impact of Postoperative Complications On Oncologic Outcomes
    • Course Complete
    • Final Assessment
Grapherence® [↑30]
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